Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.050 Biomarker BEFREE • The baseline <sup>18</sup> F-FDG PET tumor texture features can predict tumor NAC response for patients with osteosarcoma. 30859285

2019

Entrez Id: 407026
Gene Symbol: MIR29C
MIR29C
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.040 AlteredExpression BEFREE Τhe relative expression of miR-29c in osteosarcoma tissue was significantly lower than that in paraneoplastic tissue (P<0.05). 31186756

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 AlteredExpression BEFREE β-catenin protein expression was, however, detected in the membrane and cytoplasm of 69.6% (32/46) of the osteosarcomas. c-myc protein expression was detected in only 47.8% (22/46) and cyclin D1 protein expression in 52.2% (24/46) of osteosarcoma samples. 24942472

2014

Entrez Id: 29843
Gene Symbol: SENP1
SENP1
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.030 AlteredExpression BEFREE [Corrigendum] Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV. 30896859

2019

Entrez Id: 26073
Gene Symbol: POLDIP2
POLDIP2
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160

2019

Entrez Id: 10598
Gene Symbol: AHSA1
AHSA1
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160

2019

Entrez Id: 9402
Gene Symbol: GRAP2
GRAP2
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160

2019

Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160

2019

Entrez Id: 25897
Gene Symbol: RNF19A
RNF19A
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160

2019

Entrez Id: 7965
Gene Symbol: AIMP2
AIMP2
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160

2019

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160

2019

Entrez Id: 1398
Gene Symbol: CRK
CRK
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160

2019

Entrez Id: 2658
Gene Symbol: GDF2
GDF2
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.080 Biomarker BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160

2019

Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.050 AlteredExpression BEFREE [3H]Thymidine (TdR) incorporation by human osteosarcoma cell line MG-63 was significantly stimulated at as early as 3 h after the addition of either TIMP-1 or TIMP-2 alone. 8906876

1996

Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.020 AlteredExpression BEFREE [3H]Thymidine (TdR) incorporation by human osteosarcoma cell line MG-63 was significantly stimulated at as early as 3 h after the addition of either TIMP-1 or TIMP-2 alone. 8906876

1996

Entrez Id: 2021
Gene Symbol: ENDOG
ENDOG
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.010 Biomarker BEFREE Zoledronic acid activates the DNA S-phase checkpoint and induces osteosarcoma cell death characterized by apoptosis-inducing factor and endonuclease-G translocation independently of p53 and retinoblastoma status. 17050806

2007

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE ZOL induced autophagy by repressing the protein kinase B/mammalian target of rapamycin/p70S6 kinase pathway and extracellular signal-regulated kinase signaling-dependent autophagy in OS cell lines and patient-derived OS cells. 31752184

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE ZOL increased the production of IL-6 in all cell types, whereas FOS only in osteosarcoma cell, which happened in dose dependent manner. 29454604

2018

Entrez Id: 64210
Gene Symbol: MMS19
MMS19
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.020 Biomarker BEFREE XPG and MMS19L are correlated with response to chemotherapy and prognosis of osteosarcoma, so that they could be used as predictive markers for prognosis. 23886164

2013

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 AlteredExpression BEFREE Xenografted SPC24 knockdown osteosarcoma cells showed reduced tumor growth in nude mice with decreased EGFR and phospho-ERK levels and increased E-cadherin levels. 29285250

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE X-linked inhibitor of apoptosis protein inhibitor Embelin induces apoptosis via PI3K/Akt pathway and inhibits invasion in osteosarcoma cells. 30249882

2018

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE X-linked inhibitor of apoptosis protein inhibitor Embelin induces apoptosis via PI3K/Akt pathway and inhibits invasion in osteosarcoma cells. 30249882

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE X-linked inhibitor of apoptosis protein inhibitor Embelin induces apoptosis via PI3K/Akt pathway and inhibits invasion in osteosarcoma cells. 30249882

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE X-linked inhibitor of apoptosis protein inhibitor Embelin induces apoptosis via PI3K/Akt pathway and inhibits invasion in osteosarcoma cells. 30249882

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker BEFREE WWOX promoted apoptosis and inhibited invasion and expression of bcl-2, OPN, RUNX2, and VEGF in osteosarcoma cells <i>in vitro</i>. 28977834

2017